MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
Yujing Wang, Tao Wei, Wei Zhao, Zixuan Ren, Yan Wang, Yiding Zhou, Xun Song, Ruidong Zhou, Xiaochu Zhang, Dongliang Jiao
Abstract
The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD.
Topics & Concepts
Endoplasmic-reticulum-associated protein degradationMeth-MethamphetaminemicroRNADownregulation and upregulationUbiquitinAddictionEndoplasmic reticulumBiologyCell biologyPharmacologyBioinformaticsChemistryNeuroscienceBiochemistryGeneUnfolded protein responseOrganic chemistryPolymerMonomerAcrylateEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyMicroRNA in disease regulation