Recent advances in using liposomes for delivery of nucleic acid-based therapeutics
Hamdi Nsairat, Walhan Alshaer, Fadwa Odeh, Ezaldeen Esawi, Dima Khater, Abeer Al Bawab, Mohamed El‐Tanani, Abdalla Awidi, Mohammad S. Mubarak
Abstract
Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class of therapeutics may change the field of disease treatment and personalized medicine since it can cure diseases. However, drug delivery systems are crucial for these therapeutics to fulfill their potential. Liposomes have long been considered ideal platforms for systemic drugs delivery. Considering the development in cancer therapeutics, this work emphases on the current advancements in liposomes’ Nano-formulations, functionalization, and design and how it has been applied to nucleic acid therapeutics. Accordingly, this review covers the literature that deals with liposomes in nucleic acid therapy.