Improving Acetic Acid and Furfural Resistance of Xylose-Fermenting Saccharomyces cerevisiae Strains by Regulating Novel Transcription Factors Revealed via Comparative Transcriptomic Analysis
Bo Li, Li Wang, Yajing Wu, Ziyuan Xia, Bai-Xue Yang, Yue‐Qin Tang
Abstract
strain in response to acetic acid and furfural. The transcription factor Haa1p was found to be involved in both acetic acid and furfural tolerance. In addition to Haa1p, four other transcription factors, Hap4p, Yox1p, Tye7p, and Mga1p, were identified as able to improve the resistance of yeast to these two inhibitors. This study underscores the feasibility of uncovering effective transcription factors for constructing robust strains for lignocellulosic bioethanol production.
Topics & Concepts
XyloseHydrolysateFermentationFurfuralSaccharomyces cerevisiaeBiochemistryChemistryXylose metabolismAcetic acidYeastBiologyMicrobiologyFood scienceHydrolysisCatalysisBiofuel production and bioconversionMicrobial Metabolic Engineering and BioproductionFungal and yeast genetics research