Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice
Hui Qiao, Yuan Tian, Yuda Huo, Heng‐Ye Man
Abstract
(IUE), it results in abnormal migration of newborn neurons and increased dendritic arborization. Importantly, intraventricular brain injection of AAV-USP7 in P0 mice leads to autistic-like phenotypes including aberrant social interactions, repetitive behaviors, as well as changes in somatosensory sensitivity. These findings provide new insights in USP7-related neurobiological functions and its implication in ASD.
Topics & Concepts
HaploinsufficiencyXIAPAutismBiologyPathogenesisDendritic spineGene knockdownPhenotypeNeuroscienceCell biologyImmunologyApoptosisCaspaseMedicineGeneProgrammed cell deathGeneticsHippocampal formationPsychiatryGenetics and Neurodevelopmental DisordersUbiquitin and proteasome pathwaysAutism Spectrum Disorder Research