DDX56 Binds to Chikungunya Virus RNA To Control Infection
Frances Taschuk, Iulia Tapescu, Ryan H. Moy, Sara Cherry
Abstract
Arthropod-borne viruses are diverse pathogens and include the emerging virus chikungunya virus, which is associated with human disease. Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus in insects and humans. DDX56 relocalizes from the nucleus to the cytoplasm, where it binds to a stem-loop in the viral genome and destabilizes incoming genomes. Thus, DDX56 is an evolutionarily conserved antiviral factor that controls alphavirus infection.
Topics & Concepts
ChikungunyaVirologyVirusAlphavirusBiologyRNARNA virusComputational biologyGeneticsGeneViral Infections and VectorsMosquito-borne diseases and controlinterferon and immune responses