Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases
Xinyue Chen, Russell Hughes, Nic Mullin, Raymond J. Hawkins, Ingunn Holen, Nicola J. Brown, Jamie K. Hobbs
Abstract
cultured cancer cells and subcutaneous tumour explants. The presence of mechanically distinct metastatic tumour did not result in alterations of the mechanical properties of the surrounding microenvironment at meso-scale distances (>200 μm). These findings demonstrate the utility of atomic force microscopy in studies of complex tissues and provide new insights into the mechanical properties of cancer metastases in bone.
Topics & Concepts
Atomic force microscopyBreast cancerMaterials scienceMicroscopyIn vitroCancerBiomedical engineeringMedicineCancer researchNanotechnologyPathologyChemistryInternal medicineBiochemistryCellular Mechanics and InteractionsForce Microscopy Techniques and Applicationsthermodynamics and calorimetric analyses