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New prediction categories in <scp>CASP15</scp>

Andriy Kryshtafovych, Maciej Antczak, Marta Szachniuk, Tomasz Żok, Rachael C. Kretsch, Ramya Rangan, Phillip Pham, Rhiju Das, Xavier Robin, Gabriel Studer, Janani Durairaj, Jérôme Eberhardt, Aaron Sweeney, Maya Topf, Torsten Schwede, Krzysztof Fidelis, John Moult

2023Proteins Structure Function and Bioinformatics61 citationsDOIOpen Access PDF

Abstract

Prediction categories in the Critical Assessment of Structure Prediction (CASP) experiments change with the need to address specific problems in structure modeling. In CASP15, four new prediction categories were introduced: RNA structure, ligand-protein complexes, accuracy of oligomeric structures and their interfaces, and ensembles of alternative conformations. This paper lists technical specifications for these categories and describes their integration in the CASP data management system.

Topics & Concepts

CASPProtein structure predictionComputer scienceComputational biologyProtein structureData miningChemistryBiologyBiochemistryRNA and protein synthesis mechanismsProtein Structure and DynamicsEnzyme Structure and Function