Astragalus polysaccharide (APS) exerts protective effect against acute ischemic stroke (AIS) through enhancing M2 micoglia polarization by regulating adenosine triphosphate (ATP)/ purinergic receptor (P2X7R) axis
Xiang Jia, Liying Xie, Yuan Liu, Tianfu Liu, Peiqun Yang, Jianfang Hu, Zhichao Peng, Kangrui Luo, Min Du, Chaojun Chen
Abstract
. Furthermore, APS inhibited the expression of P2X7R by promoting the degradation of adenosine triphosphate (ATP) in the cerebral cortex of MCAO rats. In addition, APS contributed to maintain the integrity of BBB. Summarily, APS can reduce brain injury by promoting the degradation of ATP in microglia and inhibiting the expression of P2X7R after AIS.
Topics & Concepts
MicrogliaPurinergic receptorWestern blotAdenosine triphosphatePurinergic signallingPharmacologyFlow cytometryChemistryAdenosineCell biologyIn vivoMedicineReceptorAdenosine receptorInflammationBiologyMolecular biologyImmunologyBiochemistryAgonistGeneBiotechnologyNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsAdenosine and Purinergic Signaling