The synergistic effect of Cu-MOF nanoparticles and immunomodulatory agent on SARS-CoV-2 inhibition
Aleksander Ejsmont, Alicja Warowicka, Justyna Broniarczyk, Joanna Gościańska
Abstract
In this work, HKUST-1 and Cu-BDC nanoparticles were used as delivery systems for the early anti-COVID-19 drug, hydroxychloroquine. The antiviral MOF/drug combinations significantly reduced the infectivity of SARS-CoV-2, which can be attributed to the nanometric size of the carriers, the presence of copper in the MOF nodes, and the semi-controlled release of the drug.
Topics & Concepts
HydroxychloroquineInfectivityNanoparticleDrugDrug deliverySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)ChemistryDrug carrier2019-20 coronavirus outbreakNanotechnologyVirologyPharmacologyMaterials scienceVirusMedicineOrganic chemistryDiseaseInfectious disease (medical specialty)OutbreakPathologyMetal-Organic Frameworks: Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisMXene and MAX Phase Materials