Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase
Yaoliang Sun, Ying Zhang, Xiaoai Chen, Aisong Yu, Wenhao Du, Yuting Huang, Feifei Wu, Lei Yu, Jiayi Li, Cuiyun Wen, Hong Yang, Qiongyu Shi, Meiyu Geng, Xun Huang, Shilin Xu
Topics & Concepts
ChemistryBromodomainCancer researchMethylationProteolysisFusion proteinA549 cellHistoneCell biologyEpigeneticsApoptosisBiochemistryGeneEnzymeBiologyRecombinant DNAProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysCancer-related gene regulation