<i>ortho</i>-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3<i>H</i>)-ones: a convergent synthetic route to bouchardatine and sildenafil
Kyeongha Kim, Hun Young Kim, Kyungsoo Oh
Abstract
-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner.
Topics & Concepts
CatalysisChemistryNaphthoquinone1,4-NaphthoquinoneMedicinal chemistryCombinatorial chemistryOrganic chemistryQuinazolinone synthesis and applicationsPhenothiazines and Benzothiazines Synthesis and ActivitiesAdvanced Synthetic Organic Chemistry