Benvitimod Inhibits IL-4– and IL-13–Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes
Xiaojie Wang, Dandan Mao, Jun Jia, Jianzhong Zhang
Topics & Concepts
STAT proteinAryl hydrocarbon receptor nuclear translocatorDownregulation and upregulationSTAT6HaCaTTight junctionAryl hydrocarbon receptorSignal transductionBiologyPhosphorylationCell biologyActivator (genetics)STAT1Cancer researchTranscription factorChemistryMolecular biologySTAT3ReceptorIn vitroGeneBiochemistryDermatology and Skin DiseasesAllergic Rhinitis and SensitizationAsthma and respiratory diseases