Fe(OTf)<sub>3</sub>- and γ-Cyclodextrin-Catalyzed Hydroamination of Alkenes with Carbazoles
En‐Kai Xiao, Xian‐Tao Wu, Feng Ma, Xiaohua Feng, Peng Chen, Yijun Jiang
Abstract
A Fe(OTf)3- and γ-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is demonstrated. This biomimetic-catalyst-oriented sustainable and green method could deliver a wide scope of N-alkylated carbazoles and N-alkylated-carbazole-fused aromatics in up to 97% yield. The salient features of this transformation include simple and benign reaction conditions with no need for a strong base, additive, or the irradiation of light.
Topics & Concepts
HydroaminationChemistryCarbazoleCatalysisCyclodextrinAlkylationYield (engineering)Combinatorial chemistryAminationOrganic chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsChemical Synthesis and Reactions