Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy
Shanmeng Lin, Liwei Zhu, Zhiying Li, Siyuan Yue, Zhaohan Wang, Youwei Xu, Yichuan Zhang, Quan Gao, Jie Chen, Ting Yin, Lili Niu, Jin Geng
Abstract
Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and acrylate mannose (MAN). The block copolymer was then self-assembled to produce micelles. The chemotherapy drug dasatinib (DAS) and the sonodynamic therapy agent methylene blue (MB) were encapsulated by the self-assembly of the block copolymer. This targeted nanoparticle enables sonodynamic therapy through high-intensity focused ultrasound while triggering nanoparticle disassembly for controlled drug release. The ultrasound-mediated, non-invasive strategy provides external spatiotemporal control for targeted tumour treatment.