Tumor-targeted superfluorinated micellar probe for sensitive <i>in vivo</i><sup>19</sup>F-MRI
Lucie Jamgotchian, Solenne Vaillant, Erwan Selingue, Anaëlle Doerflinger, Agathe Bélime, Marie Vandamme, Guillaume Pinna, Wai Li Ling, Edmond Gravel, Sébastien Mériaux, Eric Doris
Abstract
We describe herein the assembly and in vivo evaluation of a tailor-made micellar carrier system designed for the optimized encapsulation of a superfluorinated MRI probe and further targeting of solid tumors. The in vivo validation was carried out on MC38 tumor-bearing mice which allowed the confirmation of the efficient targeting properties of the nano-carrier, as monitored by 19F-MRI.
Topics & Concepts
In vivoMaterials scienceNanotechnologyNuclear magnetic resonanceMedical physicsChemistryPhysicsBiologyBiotechnologyLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsMagnetism in coordination complexes