International consensus on the use of tau PET imaging agent 18F-flortaucipir in Alzheimer’s disease
Mei Tian, A. Cahid Civelek, Ignasi Carrió, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, Valentina Garibotto, John O. Prior, Henryk Barthel, Rui Zhou, Haifeng Hou, Xiaofeng Dou, Chentao Jin, Chuantao Zuo, Hong Zhang, Molecular Imaging-based Precision Medicine Task Group of A3 (China-Japan-Korea) Foresight Program
Abstract
Abstract Purpose Positron emission tomography (PET) with the first and only tau targeting radiotracer of 18 F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology deposition and distribution in patients with cognitive impairment. The goal of this international consensus is to help nuclear medicine practitioners procedurally perform 18 F-flortaucipir PET imaging. Method A multidisciplinary task group formed by experts from various countries discussed and approved the consensus for 18 F-flortaucipir PET imaging in Alzheimer’s disease (AD), focusing on clinical scenarios, patient preparation, and administered activities, as well as image acquisition, processing, interpretation, and reporting. Conclusion This international consensus and practice guideline will help to promote the standardized use of 18 F-flortaucipir PET in patients with AD. It will become an international standard for this purpose in clinical practice.