Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury
Yong Zhang, Xueqian Chen, Qing Yuan, Yongning Bian, Mingrui Li, Yaling Wang, Xueyun Gao, Dongdong Su
Abstract
We rationally designed a leucine aminopeptidase (LAP) activated fluorogenic probe hCy-CA-LAP with high hepatocyte-targeting ability for accurate and sensitive imaging of DILI.
Topics & Concepts
AminopeptidaseLiver injuryHepatocyteDrugChemistryEnzymeLeucineBiochemistryCancer researchPharmacologyMedicineIn vitroAmino acidDrug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and ProtectionSulfur Compounds in Biology