Long non-coding RNA HOTAIR regulates myeloid differentiation through the upregulation of p21 via miR-17-5p in acute myeloid leukaemia
Linhui Hu, Jun Liu, Meng Ye, Huimin Zheng, Chen Ding, Huiping Wang, Alice Charwudzi, Manman Li, Jingrong Li, Zhimin Zhai, Shudao Xiong
Abstract
AML: acute myeloid leukaemia; APL: acute promyelocytic leukaemia; ATRA: all-trans retinoic acid; CCK8: cell Counting Kit-8; CDKs: cyclin-dependent kinases ; CeRNA: competing endogenous RNAs; ChIP: chromatin immunoprecipitation; CHX: cycloheximide; FAB: French-American-British; FCM: flow cytometry; HOTAIR: HOX transcript antisense RNA; IDA: iron-deficiency anemia; lncRNA: long non-coding RNA; 3'UTR: 3'untranslated region; MT: Mutation type; WT: Wild type; qRT-PCR: Quantitative real-time PCR.
Topics & Concepts
HOTAIRBiologyLong non-coding RNAMyeloidDownregulation and upregulationCancer researchmicroRNAMyeloid leukaemiaMyeloid cellsRNAMyeloid leukemiaGeneGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesMicroRNA in disease regulation