Associations of the atherogenic index of plasma with insulin resistance and inflammation
Yasin Altun, Halime Balci, Nilay Çom Aybal
Abstract
OBJECTIVE: This study aimed to investigate the association between the atherogenic index of plasma and insulin resistance, while also evaluating atherogenic index of plasma's prognostic value in inflammation by examining its correlation with platelet/lymphocyte ratio and neutrophil/lymphocyte ratio. METHODS: Data collection involved accessing records from January 2022 to December 2022, with analyses including calculation of atherogenic index of plasma and homeostatic model assessment index. RESULTS: Data from 510 patients (mean age: 48.90±18.71 years; 69.4% female) showed a mean atherogenic index of plasma of 0.40±0.28, with 69% at high risk. Significant positive correlations were found between atherogenic index of plasma and age, lymphocyte, neutrophil, C-reactive protein, glucose, insulin, and homeostatic model assessment-insulin resistance, while the correlation with platelet/lymphocyte ratio was significantly negative. CONCLUSION: Atherogenic index of plasma presents as a promising predictor for insulin resistance, demonstrating robust associations with inflammation, thus offering valuable clinical insights and potential for early risk assessment and management strategies.