Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses
Nathan G. Lawler, Nicola Gray, Torben Kimhofer, Berin A. Boughton, Melvin Gay, Rongchang Yang, Aude-Claire Morillon, Sung‐Tong Chin, Monique Ryan, Sofina Begum, Sze-How Bong, Jérôme D. Coudert, Dale W. Edgar, Edward Raby, Sven Pettersson, Toby Richards, Elaine Holmes, Luke Whiley, Jeremy K. Nicholson
Abstract
< 0.05). This signature supports a systemic metabolic phenoconversion following infection, indicating possible neurotoxicity and neurological disruption (elevations of 3-hydroxykynurenine and quinolinic acid) and liver dysfunction (reduction in Fischer's ratio and elevation of taurine). Finally, we report correlations between the key metabolite changes observed in the disease with concentrations of proinflammatory cytokines and chemokines showing strong immunometabolic disorder in response to SARS-CoV-2 infection.