Intervening in Symbiotic Cross-Kingdom Biofilm Interactions: a Binding Mechanism-Based Nonmicrobicidal Approach
H. E. Kim, Atul Dhall, Yuan Liu, Marwa Bawazir, Hyun Koo, Geelsu Hwang
Abstract
surface mediate the cross-kingdom interaction, we demonstrated that mannoprotein-degrading enzymes can effectively disrupt biofilm interactions without microbiocidal effects or causing cytotoxicity to human cells. This suggests a potential application as a targeted approach for intervening a pathogenic cross-kingdom biofilm associated with a costly and unresolved oral disease.
Topics & Concepts
BiofilmMechanism (biology)Computational biologyChemistryMicrobiologyComputer scienceBiologyBacteriaEpistemologyGeneticsPhilosophyBacterial biofilms and quorum sensingMicrobial Community Ecology and PhysiologyMicrobial Fuel Cells and Bioremediation