Electrochemical thiocyanation of barbituric acids
Oleg V. Bityukov, Andrey S. Kirillov, Pavel Yu. Serdyuchenko, М. А. Кузнецова, V.N. Demidova, Vera A. Vil’, Alexander O. Terent’ev
Abstract
from the thiocyanate anion. The addition of thiocyanogen to the double bond of the enol tautomer of barbituric acid gives thiocyanated barbituric acid. A variety of thiocyanated barbituric acids bearing different functional groups were obtained in 18-95% yields and were shown to exhibit promising antifungal activity.
Topics & Concepts
Barbituric acidElectrochemistryChemistryCombinatorial chemistryOrganic chemistryElectrodePhysical chemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsPhenothiazines and Benzothiazines Synthesis and Activities