Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression
Kalina Timcheva, Solenne Dufour, Leila Touat‐Todeschini, Callum Burnard, Marie‐Christine Carpentier, Florent Chuffart, Rémy Merret, Marion Helsmoortel, Sabrina Ferré, Aude Grézy, Yohann Couté, Sophie Rousseaux, Saadi Khochbin, Claire Vourc’h, Cécile Bousquet‐Antonelli, Rosemary Kiernan, Daphné Seigneurin‐Berny, André Verdel
Abstract
A-based reprogramming of gene expression during HS. Furthermore, they support the model where the subsequent and temporary sequestration of YTHDC1 within nSBs calibrates the timing of this YTHDC1-dependent gene expression reprogramming.
Topics & Concepts
ReprogrammingChromatinGene expressionCell biologyGeneBiologyGeneticsRegulation of gene expressionRNA modifications and cancerRNA Research and SplicingGenomics and Chromatin Dynamics