Scalable Electrocatalytic Intermolecular Acylcyanation and Aminocyanation of Alkenes
Xianqiang Kong, Xiaohui Chen, Yiyi Chen, Zhong‐Yan Cao
Abstract
Electrocatalytic three-component acylcyanation and aminocyanation of simple alkenes have been developed. The protocol features high functional group tolerance and can easily be scaled up. The key to success is to use an electrophilic cyanation source, enabling a broadened use of alkenes to aliphatic ones for acylcyanation.
Topics & Concepts
ChemistryCyanationElectrophileIntermolecular forceCombinatorial chemistryKey (lock)Component (thermodynamics)Protocol (science)Organic chemistryMoleculeCatalysisAlternative medicineMedicinePhysicsEcologyPathologyThermodynamicsBiologyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques