CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir
Thomas Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene
Abstract
T cells that become infected and form a significant reservoir for latent infection. Furthermore, we show that blockade of CCL2 in humanized mice significantly reduces persistent HIV infection. This information is relevant to the development of therapeutics to prevent and/or treat chronic HIV infections.
Topics & Concepts
CCR2ChemokineImmunologyCCL2Immune systemInnate immune systemVirologyBiologyProvirusChemokine receptorMedicineInflammationGenomeGeneBiochemistryHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology