H1 Hemagglutinin Priming Provides Long-Lasting Heterosubtypic Immunity against H5N1 Challenge in the Mouse Model
Juan Manuel Carreño, Shirin Strohmeier, Ericka Kirkpatrick Roubidoux, Rong Hai, Peter Palese, Florian Krammer
Abstract
Current studies point out that an HA-mediated immunological imprint is established early in life during the first exposure to influenza viruses, which critically shapes and biases future immune responses. However, studies in animal models are limited and the precise mechanisms of this phenomenon are under investigation. Studies that explore the effect of HA-specific immunity induced during natural infection on future exposures to heterosubtypic influenza strains are needed.
Topics & Concepts
Influenza A virus subtype H5N1Hemagglutinin (influenza)VirologyBiologyImmunityImmunologyImmune systemAntibodyInfluenza A virusVaccinationVirusPriming (agriculture)MicrobiologyBotanyGerminationInfluenza Virus Research StudiesRespiratory viral infections researchImmune Response and Inflammation