2-Phenethylamines in Medicinal Chemistry: A Review
Carlos T. Nieto, Alejandro Manchado, Leland Belda, David Dı́ez, Narciso M. Garrido
Abstract
A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.
Topics & Concepts
PhenethylaminesChemistryAlicyclic compoundOrganic chemistryStereochemistryReceptor Mechanisms and SignalingPharmacogenetics and Drug MetabolismPharmacological Receptor Mechanisms and Effects