Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci
Hamish W. King, Kristen L. Wells, Zohar Shipony, Arwa S. Kathiria, Lisa E. Wagar, Caleb A. Lareau, Nara Orban, Robson Capasso, Mark M. Davis, Lars M. Steinmetz, Louisa K. James, William J. Greenleaf
Abstract
). Together, these analyses provide a powerful new cell type–resolved resource for the interpretation of cellular and genetic causes underpinning autoimmune disease.
Topics & Concepts
BiologyEpigenomicsGerminal centerTranscriptomeEpigenomeBCL6Immune systemGeneticsTranscription factorAutoimmunityAcquired immune systemEpigeneticsInnate lymphoid cellB cellImmunologyGeneGene expressionDNA methylationAntibodyImmune Cell Function and InteractionT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways