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Advances in Self-Assembled Peptides as Drug Carriers

Yawen Gao, Lele Wang, Xue Zhang, Ziling Zhou, Xinzhu Shen, Haodong Hu, Rui Sun, Jihui Tang

2023Pharmaceutics36 citationsDOIOpen Access PDF

Abstract

In recent years, self-assembled peptide nanotechnology has attracted a great deal of attention for its ability to form various regular and ordered structures with diverse and practical functions. Self-assembled peptides can exist in different environments and are a kind of medical bio-regenerative material with unique structures. These materials have good biocompatibility and controllability and can form nanoparticles, nanofibers and hydrogels to perform specific morphological functions, which are widely used in biomedical and material science fields. In this paper, the properties of self-assembled peptides, their influencing factors and the nanostructures that they form are reviewed, and the applications of self-assembled peptides as drug carriers are highlighted. Finally, the prospects and challenges for developing self-assembled peptide nanomaterials are briefly discussed.

Topics & Concepts

NanotechnologyBiocompatibilityNanofiberSelf-healing hydrogelsSelf-assemblyNanomaterialsSelf-assembling peptideMaterials scienceMetallurgyPolymer chemistrySupramolecular Self-Assembly in MaterialsPolydiacetylene-based materials and applicationsRNA Interference and Gene Delivery