Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
Chunhong Jia, Zhoushan Feng, Xiaojun Lin, Qiliang Cui, Shasha Han, Ya Jin, Guosheng Liu, Chuanzhong Yang, Xiaotong Ye, Yiheng Dai, Wei-Yi Liang, Xiu-Zhen Ye, Jing Mo, Lu Ding, Benqing Wu, Hongxiang Chen, Chi‐Wang Li, Zhe Zhang, Rong Xiao, Weimin Huang, Wei Shen, Bingyan Yang, Jun-Feng Lv, Le-Ying Huo, Huiwen Huang, Hongping Rao, Wenkang Yan, Yong Yang, Xuejun Ren, Dong Liu, Fangfang Wang, Shi-Guang Diao, Xiaoyan Liu, Chuming You, Qiong Meng, Bin Wang, Lijuan Zhang, Yuge Huang, Dang Ao, Weizhong Li, Jie-Ling Chen, Yanling Chen, Wei Li, Zhifeng Chen, Yueqin Ding, Xiaoyu Li, Yuefang Huang, Niyang Lin, Yangfan Cai, Zhong-He Wan, Yi Ban, Bo Bai, Guanghong Li, Yue-Xiu Yan, Fan Wu
Abstract
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units in Guangdong Province of China during 2008-2017 were analyzed. A total of 2575 ELBW infants were enrolled and the overall survival rate was 55.11%. From 2008 to 2017, the number of ELBW infants increased rapidly from 91 to 466, and the survival rate improved steadily from 41.76% to 62.02%. Increased survival is closely related to birth weight (BW), regional economic development, and specialized hospital. The incidence of complications was neonatal respiratory distress syndrome (85.2%), oxygen dependency at 28 days (63.7%), retinopathy of prematurity (39.3%), intraventricular hemorrhage (29.4%), necrotizing enterocolitis (12.0%), and periventricular leukomalacia (8.0%). Among the 1156 nonsurvivors, 90.0% of infants died during the neonatal period (≤ 28 days). A total of 768 ELBW infants died after treatment withdrawal, for reasons of economic and/or poor outcome. The number of ELBW infants is increasing in Guangdong Province of China, and the overall survival rate is improving steadily.