Long noncoding RNA DLGAP1-AS1 promotes the progression of glioma by regulating the miR-1297/EZH2 axis
Liang Liu, Xiaojian Li, Yan Shi, Hua Chen
Abstract
glioma cell invasion, migration and proliferation. DLGAP1-AS1 was found to function as a miR-1297 sponge, based on information from luciferase reporter assays, RNA pull-down assays and publicly available online databases. miR-1297 was in turn found to functionally target EZH2. DLGAP1-AS1 modulated EZH2 expressions through miR-1297 sponging. Glioma progression appears to be supported DLGAP1-AS1 -promoted activation of the miR-1297/EZH2 axis. The components of this axis may function as therapeutic targets for glioma.
Topics & Concepts
Long non-coding RNAmicroRNAEZH2GliomaRNANon-coding RNACancer researchBiologyCell biologyGeneticsEpigeneticsGeneCancer-related molecular mechanisms researchCircular RNAs in diseasesMicroRNA in disease regulation