Intestinal Osteopontin Protects From Alcohol-induced Liver Injury by Preserving the Gut Microbiome and the Intestinal Barrier Function
Sukanta Das, Zhuolun Song, Hui Han, Xiaodong Ge, Romain Désert, Dipti Athavale, Sai Santosh Babu Komakula, Fernando Magdaleno, Wei Chen, Daniel D. Lantvit, Grace Guzman, Natalia Nieto
Abstract
BACKGROUND & AIMS: develop worse ALD than wild-type (WT) mice; however, the role of intestinal osteopontin (OPN) in ALD remains unknown. We hypothesized that overexpression of OPN in intestinal epithelial cells (IECs) could ameliorate ALD by preserving the gut microbiome and the intestinal barrier function. METHODS: , and WT mice were fed control or ethanol Lieber-DeCarli diet for 6 weeks. RESULTS: mice in ALD. CONCLUSION: Overexpression of OPN in IECs or administration of milk OPN maintain the intestinal microbiome by intestinal antimicrobial peptides. The increase in tryptophan metabolites and short-chain fatty acids signaling through the Ahr in IECs, preserve the intestinal barrier function and protect from ALD.