Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production
Ravi Holani, Anshu Babbar, Graham A. D. Blyth, Fernando Lopes, Humberto Jijon, Derek M. McKay, Morley D. Hollenberg, Eduardo R. Cobo
Abstract
. We conclude that in addition to its known microbicidal action, cathelicidin has a unique pathogen-sensing role, facilitating LPS-mediated intestinal responses, including the production of CXCL8/CXCL1 that would contribute to an integrated tissue response to recruit neutrophils during colitis.
Topics & Concepts
CathelicidinCXCL1BiologyTLR4Cell biologyInterleukin 8TLR2SecretionAntimicrobial peptidesSignal transductionImmunologyInnate immune systemChemokineInflammationMicrobiologyImmune systemAntimicrobialEndocrinologyAntimicrobial Peptides and ActivitiesImmune Response and InflammationNeonatal and Maternal Infections