Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis
Rakesh Bhatia, Jawed A. Siddiqui, Koelina Ganguly, Christopher M. Thompson, Andrew Cannon, Abhijit Aithal, Naveenkumar Perumal, Shailendra Kumar Maurya, Xiaoqi Li, Jesse L. Cox, Channabasavaiah B. Gurumurthy, Satyanarayana Rachagani, Maneesh Jain, Mohd W. Nasser, Surinder K. Batra, Sushil Kumar
Topics & Concepts
BiologyEpidermal growth factor receptorEctodomainPancreatic Intraepithelial NeoplasiaCancer researchKRASCarcinogenesisGrowth factor receptorConditional gene knockoutSignal transductionReceptorPhenotypeCancerCell biologyGeneticsGeneColorectal cancerBiochemistryPancreatic and Hepatic Oncology ResearchGlycosylation and Glycoproteins ResearchGalectins and Cancer Biology