Targeted nanoscale therapeutics for myocardial infarction
Holly L. Sullivan, Nathan C. Gianneschi, Karen L. Christman
Abstract
Nanoscale therapeutics have promise for the administration of therapeutic small molecules and biologics to the heart following myocardial infarction. Directed delivery to the infarcted region of the heart using minimally invasive routes is critical to this promise. In this review, we will discuss the advances and design considerations for two nanoscale therapeutics engineered to target the infarcted heart, nanoparticles and adeno-associated viruses.
Topics & Concepts
Myocardial infarctionNanoscopic scaleCardiologyMedicineInternal medicineNanotechnologyMaterials scienceSignaling Pathways in DiseaseCardiac Structural Anomalies and RepairPeptidase Inhibition and Analysis