Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions.
Derek J. Leishman, Jessica C. Brimecombe, William Crumb, Simon Hebeisen, S. G. Jenkinson, Peter J. Kilfoil, Hiroshi Matsukawa, Karim Melliti, Yusheng Qu
Topics & Concepts
hERGMargin (machine learning)QT intervalControl (management)MedicinePharmacologyInternal medicineReliability engineeringRisk analysis (engineering)Computer scienceEngineeringArtificial intelligenceMachine learningPotassium channelCardiac electrophysiology and arrhythmiasAcute Myocardial Infarction ResearchTakotsubo Cardiomyopathy and Associated Phenomena