The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration
Da‐Yo Yuh, Tomoki Maekawa, Xiaofei Li, Tetsuhiro Kajikawa, Khalil Bdeir, Triantafyllos Chavakis, George Hajishengallis
Abstract
) and by mineralized nodule formation, depended on its capacity to induce the phosphorylation of focal adhesion kinase (FAK) and of extracellular signal-regulated kinase 1/2 (ERK1/2). We conclude that DEL-1 can activate a β3 integrin-FAK-ERK1/2-RUNX2 pathway in osteoprogenitors and promote new bone formation in mice. These findings suggest that DEL-1 may be therapeutically exploited to restore bone lost due to periodontitis and perhaps other osteolytic conditions.
Topics & Concepts
RUNX2Cell biologyIntegrinRGD motifChemistryExtracellular matrixMolecular biologyOsteoblastBiologyIn vitroReceptorBiochemistryCell Adhesion Molecules ResearchBlood disorders and treatmentsImmune Response and Inflammation