Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1+ monocytes-derived macrophages
Xinran Yuan, Xiaodong Qin, Kenji Takemoto, Jian Zhao, Matthew Sanderson, Xue Xu, Yu Zhang, Kristi L. Helke, Bethany J. Wolf, Joel M. Guthridge, Judith A. James, Xiaodong Zhou, Shervin Assassi, Carol Feghali‐Bostwick, Dandan Wang, Lingyun Sun, Betty P. Tsao
Topics & Concepts
MedicineBleomycinPulmonary fibrosisImmunologyFibrosisMultiple sclerosisPhagocytosisPathologyInternal medicineChemotherapySystemic Sclerosis and Related DiseasesInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisEosinophilic Disorders and Syndromes