Bioactives and their metabolites from <i>Tetrastigma hemsleyanum</i> leaves ameliorate DSS-induced colitis <i>via</i> protecting the intestinal barrier, mitigating oxidative stress and regulating the gut microbiota
Tong Wu, Xiaoya Wang, Hua Xiong, Zeyuan Deng, Xin Peng, Lihua Xiao, Li Jiang, Yong Sun
Abstract
which is positively correlated with pro-inflammatory cytokines. These results indicated that THL effectively inhibited DSS-induced colitis by maintaining the intestinal epithelial barrier, mitigated oxidative stress through regulating the Keap1/Nrf2 signaling pathway and regulated the imbalance of the intestinal flora structure.
Topics & Concepts
ColitisOccludinChemistryProinflammatory cytokineGut floraBiochemistryOxidative stressPharmacologyDigestion (alchemy)Food scienceBiologyTight junctionInflammationImmunologyChromatographyGut microbiota and healthProbiotics and Fermented FoodsBarrier Structure and Function Studies