Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine
Ling Gao, Fan Qiu, Hao Cao, Hao Li, Gonghua Dai, Teng Ma, Yanshan Gong, Wei Luo, Dongling Zhu, Zhixuan Qiu, Ping Zhu, Shu-Guang Chu, Huang‐Tian Yang, Zhongmin Liu
Abstract
This targeted microRNA delivery presents an effective and safe strategy as a stem cell and exosomal therapy in I/R cardiac repair.
Topics & Concepts
Mesenchymal stem cellCardioprotectionExosomeCancer researchAngiogenesisCardiac function curvemicroRNAReperfusion injuryMicrovesiclesApoptosisIschemiaMedicineInflammationPharmacologyCell biologyChemistryBiologyImmunologyHeart failureInternal medicineBiochemistryGeneCircular RNAs in diseasesExtracellular vesicles in diseaseMicroRNA in disease regulation