Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD
D. Parker Kelley, Katy Venable, Aspasia Destouni, Gerald Billac, Philip J. Ebenezer, Krisztián Stadler, Charles D. Nichols, Steven A. Barker, Joseph Francis
Abstract
R compared to 5-HT. DMT and pharmahuasca reduced ROS production in the PFC and HC, while harmaline had mixed effects. Treatments normalized 9, 12, and 14 overlapping DEGs, and pathway analysis implicated that genes were involved in ROS production, inflammation, growth factor signaling, neurotransmission, and neuroplasticity.
Topics & Concepts
HarmalineOxidative stressNeuroprotectionPharmacologyReactive oxygen speciesPrefrontal cortexBiologyChemistryInternal medicineEndocrinologyCell biologyNeuroscienceMedicineCognitionTryptophan and brain disordersNicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research