Deep Sequencing of HPV16 E6 Region Reveals Unique Mutation Pattern of HPV16 and Predicts Cervical Cancer
Wenchao Ai, Chuanyong Wu, Liqing Jia, Xiao Xiao, Xuewen Xu, Min Ren, Tian Xue, Xiaoyan Zhou, Ying Wang, Chunfang Gao
Abstract
The study provides evidence for the first time that HPV16 E6 sequences contain vital mutation features in predicting the high-grade squamous intraepithelial lesion and can reduce even more unneeded colposcopies without a loss of sensitivity to detect cervical cancer. Moreover, the D32E and H85Y variants of E6 exhibited a significantly higher ability to degrade p53, which may play a vital role in the development of cervical cancer.
Topics & Concepts
MutationCervical cancerLogistic regressionReceiver operating characteristicBiologyOncologyCohortDNA sequencingCancerMutation rateInternal medicineGeneticsMedicineComputational biologyGeneCervical Cancer and HPV ResearchReproductive tract infections researchGenital Health and Disease