The antiactivator FleN uses an allosteric mechanism to regulate σ <sup>54</sup> -dependent expression of flagellar genes in <i>Pseudomonas aeruginosa</i>
Chanchal, Priyajit Banerjee, Shikha Raghav, Hemant N. Goswami, Deepti Jain
Abstract
for transcription initiation. Disruption of the conserved protein-protein interface, by mutation, shows motility and transcription defects in vivo and multiflagellate phenotype. Our study provides a detailed mechanism used by monoflagellate bacteria to fine-tune the expression of flagellar genes to form and maintain a single flagellum.
Topics & Concepts
Pseudomonas aeruginosaAllosteric regulationMechanism (biology)GeneGene expressionChemistryMicrobiologyBiologyCell biologyComputational biologyBacteriaGeneticsPhysicsReceptorQuantum mechanicsBacterial Genetics and BiotechnologyAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing