Cadmium and molybdenum co-induce pyroptosis and apoptosis <i>via</i> the PTEN/PI3K/AKT axis in the livers of Shaoxing ducks (<i>Anas platyrhynchos</i>)
Panpan Cao, Gaohui Nie, Junrong Luo, Ruiming Hu, Guyue Li, Guoliang Hu, Caiying Zhang
Abstract
increasing Caspase-1, NLRP3, NEK7, ASC, GSDME, GSDMA, IL-1β and IL-18 mRNA levels, Caspase-1 p20, NLRP3, ASC and GSDMD protein levels, and IL-1β and IL-18 contents, and increasing Bak-1, Bax, Cyt C and Caspase-3 mRNA levels and cleaved Caspase-3/Caspase-3 protein level, and downregulating Bcl-2 mRNA level and the ratio of Bcl-2 to Bax, respectively. Overall, the results illustrate that pyroptosis and apoptosis induced by Cd or/and Mo may be associated with activating the PTEN/PI3K/AKT pathway in the livers of ducks. There may be a synergy between these two elements.
Topics & Concepts
CadmiumMolybdenumPyroptosisPTENProtein kinase BPI3K/AKT/mTOR pathwayChemistryApoptosisCancer researchBiochemistryBiologyProgrammed cell deathInorganic chemistryOrganic chemistryTrace Elements in Health