Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts
Wei Zhou, Zhangchen Zhao, Jonas B. Nielsen, Lars G. Fritsche, Jonathon LeFaive, Sarah A. Gagliano Taliun, Wenjian Bi, Maiken E. Gabrielsen, Mark J. Daly, Benjamin M. Neale, Kristian Hveem, Gonçalo R. Abecasis, Cristen J. Willer, Seunggeun Lee
Topics & Concepts
BiobankType I and type II errorsPopulation stratificationBiologySample size determinationGenetic associationScalabilityGenome-wide association studySample (material)ConfoundingStatistical hypothesis testingComputational biologyPopulationStatisticsGeneticsComputer scienceGeneMathematicsSingle-nucleotide polymorphismGenotypeDemographyChemistrySociologyChromatographyDatabaseGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsEpigenetics and DNA Methylation