Flumioxazin, a PPO inhibitor: A weight-of-evidence consideration of its mode of action as a developmental toxicant in the rat and its relevance to humans
Katsumasa Iwashita, Yoshinori Hosokawa, Ryo Ihara, Taiki Miyamoto, Mitsuhiro Otani, Jun Abe, Koji Asano, Odile Mercier, Kaori Miyata, Susan Barlow
Topics & Concepts
ToxicantMode of actionBiologyHemeEmbryonic stem cellIn vitroCell biologyInduced pluripotent stem cellOrganogenesisPharmacologyBiochemistryToxicityInternal medicineEnzymeMedicineGeneNeonatal Health and BiochemistryPorphyrin Metabolism and DisordersHeme Oxygenase-1 and Carbon Monoxide