Simultaneous analysis of carcinogenic N-nitrosamine impurities in metformin tablets using on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry
Atsushi Ishizaki, Kazutaka Ozawa, Hiroyuki Kataoka
Topics & Concepts
ChemistryChromatographyDetection limitExtraction (chemistry)Mass spectrometryFormic acidSolid-phase microextractionTandem mass spectrometrySolid phase extractionGas chromatography–mass spectrometryWater Treatment and DisinfectionPolyamine Metabolism and ApplicationsAnalytical chemistry methods development