Bromodomain-containing-protein-4 and cyclin-dependent-kinase-9 inhibitors interact synergistically in vitro and combined treatment reduces post-traumatic osteoarthritis severity in mice
Tomoaki Fukui, Jasper H. N. Yik, Basak Doyran, John M. Davis, Anne K. Haudenschild, Iannis E. Adamopoulos, Lei Han, Dominik R. Haudenschild
Topics & Concepts
In vivoOsteoarthritisBromodomainInflammationCancer researchBRD4CartilageTransactivationChondrocyteMedicineSynovitisIn vitroChemistryPharmacologyArthritisImmunologyPathologyGene expressionBiologyBiochemistryGeneHistoneAnatomyAlternative medicineBiotechnologyProtein Degradation and InhibitorsOsteoarthritis Treatment and MechanismsClick Chemistry and Applications