Revealing the astragalin mode of anticandidal action
Marija Ivanov, Abhilash Kannan, Dejan Stojković, Jasmina Glamočlija, Simona Golič Grdadolnik, Dominique Sanglard, Marina Sokóvić
Abstract
and also affected cell membrane integrity without causing cytotoxic effect on human gingival fibroblast cells. Considering that astragalin-mediated decreased expression of efflux pumps increases the concentration of antifungal drug inside the fungal cells, a combinatorial treatment with this agent could be explored as a novel therapeutic option for candidiasis.
Topics & Concepts
AstragalinErgosterolCandida albicansPharmacologyMode of actionEffluxCorpus albicansBiofilmMicrobiologyAntimicrobialChemistryBiologyBiochemistryFlavonoidBacteriaGeneticsKaempferolAntioxidantAntifungal resistance and susceptibilityFungal Biology and ApplicationsMicrobial Natural Products and Biosynthesis