A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease
Juan M. Bustamante, Fernando Sánchez-Valdéz, Ángel M. Padilla, Brooke E. White, Wei Wang, Rick L. Tarleton
Abstract
infection in mice, demonstrate methods to therapeutically override dormancy using a currently available drug, and provide methods to monitor alternative therapeutic approaches for this, and possibly other, low-density infectious agents.
Topics & Concepts
BenznidazoleChagas diseaseTrypanosoma cruziRegimenDrugDiseaseBiologyTrypanosomiasisPharmacologyDormancyTrypanocidal agentMedicineNifurtimoxVirologyImmunologyInternal medicineParasite hostingBotanyComputer scienceGerminationWorld Wide WebTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesParasites and Host Interactions